Dihydroorotate dehydrogenase (DHODH), located in the inner membrane of mitochondria, is an iron-containing flavin-dependent enzyme. Using the cofactor ubiquinone, DHODH…
Malaria is one of the most widespread and ancient infectious diseases of humanity. In particular, Dihydroorotate dehydrogenase (DHODH) acts as…
In our previous blogs, we have introduced two compounds that have antimalarial activity, BDA-410 and UCT943. BDA-410 is a calpain…