p53 (Tumor protein P53; cellular tumor antigen p53; transformation-related protein 53 (TRP53)) is a regulatory protein. The p53 proteins are crucial in vertebrates, where they prevent cancer formation. As such,…
N-linked glycosylation (NLG) is the attachment of an oligosaccharide and a nitrogen atom (the amide nitrogen of an asparagine (Asn) residue of a protein) in a process called N-glycosylation. NLG…
H3K27me3 is an epigenetic modification of DNA packaging protein histone H3. Specifically, it is a marker for the trimethylation of lysine 27 on histone H3 protein. Besides, H3K27me3 is relevant…
Ovarian cancer is one of the leading causes of death in women with gynecological cancers in the United States. About 70% of ovarian cancer cases are diagnosed at a late…
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is an endoplasmic reticulum-associated stress sensor protein. PERK phosphorylates eukaryotic initiation factor 2α (eIF2α) to induce translation attenuation in response to ER…
Anaplastic lymphoma kinase (ALK) is a member of the insulin receptor superfamily. Specifically, the fusion form can activate ALK, and ALK is continuously activated. Besides, the abnormal activation of ALK abnormally…
Idiopathic pulmonary fibrosis (IPF) is a disease of progressive fibrosis and respiratory failure. Endoplasmic reticulum stress (ER stress) implicates in the pathogenesis of idiopathic pulmonary fibrosis. ER stress activates a…