Dilated cardiomyopathy (DCM) is a form of heart muscle weakness. Firstly, it shows the reduction of cardiac output, as well as thinning and enlargement of left ventricular chambers. Secondly, DCM…
Malaria remains one of the most severe and life-threatening infectious diseases. Among the various Plasmodium spp., Plasmodium falciparum is the most virulent and life-threatening form, prevailing in Southeast Asia and Africa.…
Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from an ε-N-acetyl-lysine amino acid on a histone. Specifically, selective HDAC inhibitors are as a potential anti latent…
Many malignancies, particularly leukemias, are associated with aberrant recruitment of histone deacetylases (HDACs) or with mutations in histone acetyltransferases such as EP300. In addition, Histone acetylation plays a key role…
In cancer, CG-200745 is a novel and potent hydroxamate-based pan-HDAC inhibitor. Moreover, another study from Hong Sang Choi demonstrated that CG200745 attenuates renal fibrosis in obstructive kidney disease. Epigenetic modifications…
Histone deacetylase (HDAC) enzymes, including subtypes comprising class I (HDAC1, HDAC2, HDAC3, and HDAC8) and class II (HDAC 4–7, HDAC9 and HDAC10), control the deacetylation of histone and non-histone proteins.…
Histone deacetylases (HDACs) control protein acetylation levels. HDACs catalyze the removal of acetyl groups that are responsible for the addition of acetyl groups. The 11 HDAC family members require zinc…