Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from an ε-N-acetyl-lysine amino acid on a histone.…
Many malignancies, particularly leukemias, are associated with aberrant recruitment of histone deacetylases (HDACs) or with mutations in histone acetyltransferases such…
In cancer, CG-200745 is a novel and potent hydroxamate-based pan-HDAC inhibitor. Moreover, another study from Hong Sang Choi demonstrated that…
Histone deacetylase (HDAC) enzymes, including subtypes comprising class I (HDAC1, HDAC2, HDAC3, and HDAC8) and class II (HDAC 4–7, HDAC9…
Histone deacetylases (HDACs) control protein acetylation levels. HDACs catalyze the removal of acetyl groups that are responsible for the addition…