![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/03/FNDR-20123-is-an-Orally-Active-and-a-First-in-Class-Anti-Malarial-HDAC-Inhibitor-2021-03-20.jpg)
Malaria remains one of the most severe and life-threatening infectious diseases. Among the various Plasmodium spp., Plasmodium falciparum is the most…
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Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from an ε-N-acetyl-lysine amino acid on a histone.…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/04/Pivanex-is-an-Orally-Active-HDAC-Inhibitor-with-Antimetastic-and-Antiangiogenic-Properties-2020-04-10.jpg)
Many malignancies, particularly leukemias, are associated with aberrant recruitment of histone deacetylases (HDACs) or with mutations in histone acetyltransferases such…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/10/CG-200745-Possesses-Renoprotective-Activity-by-Suppressing-Renal-Fibrosis-and-inflammation-2019-10-18.jpg)
In cancer, CG-200745 is a novel and potent hydroxamate-based pan-HDAC inhibitor. Moreover, another study from Hong Sang Choi demonstrated that…
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Histone deacetylase (HDAC) enzymes, including subtypes comprising class I (HDAC1, HDAC2, HDAC3, and HDAC8) and class II (HDAC 4–7, HDAC9…