Exceptional developments in combination antiretroviral therapy (cART) have transformed HIV/AIDS from a deadly pandemic to chronic and manageable disease. HIV-1 capsid (CA) has two structurally distinct domains, an N-terminal domain…
Histone deacetylase (HDAC) enzymes, including subtypes comprising class I (HDAC1, HDAC2, HDAC3, and HDAC8) and class II (HDAC 4–7, HDAC9 and HDAC10), control the deacetylation of histone and non-histone proteins….
Nowadays, people are no strangers to AIDS. It is a kind of infectious disease caused by HIV. The latter primarily acts on human immune system, like CD4+ T cells. These…
In general, proper immune responses depend on T-cell activation during antigen presentation. However, relaxation of t-cell stimulation often leads to autoimmune and inflammatory diseases. The use of T cell activation…
Human immunodeficiency virus (HIV) infection causes CD4 T cell depletion and immunodeficiency. Antiretroviral drugs target viral proteins, such as reverse transcriptase, protease, and integrase. Antiretroviral drugs effectively inhibit HIV. However,…