![](https://www.Immune-System-Research.com/"wp-content/uploads"/2022/05/Aplaviroc-IS-A-CCR5-INHIBITOR-2022-0508.png)
Aplaviroc (AK 602), an SDP derivative, is a potent CCR5 antagonist. Additionally, the IC50s are 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL, and…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2022/01/Rottlerin-is-a-Specific-PKC-Inhibitor-2022-01-07.jpg)
Protein kinase C (PKC) is a family of protein kinase enzymes with 15 isoforms that can regulate the protein function.…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/12/Cobicistat-is-a-Selective-CYP3A-Inhibitor-and-a-Pharmacokinetic-Enhancer-of-HIV-Inhibitors-2020-12-22.jpg)
The highly active antiretroviral therapy (HAART) can transform the human immunodeficiency virus (HIV) infection into a manageable chronic disease in…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/04/BRD3308-a-Highly-Selective-HDAC3-Inhibitor-Activates-HIV-1-Transcription-and-Disrupts-HIV-1-Latency-2020-05-02.jpg){kind=spacer}
Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from an ε-N-acetyl-lysine amino acid on a histone.…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/03/PF-3450074-is-a-HIV-1-Capsid-Protein-Inhibitor-2020-03-24.jpg)
Human immunodeficiency virus type 1 (HIV-1) infection leads to depletion of the immune dysfunction. Thereby results in immunodeficiency and vulnerability…