IBS008738 is a Potent TAZ Activator
The transcriptional coactivator with a PDZ-binding motif (TAZ, also called WWTR1) acts as an N-terminal TEAD-binding domain, one or two WW domains, and a transcriptional activation domain. The Hippo pathway…
The transcriptional coactivator with a PDZ-binding motif (TAZ, also called WWTR1) acts as an N-terminal TEAD-binding domain, one or two WW domains, and a transcriptional activation domain. The Hippo pathway…
Interleukin 10 (IL-10) is an anti-inflammatory cytokine. Specifically, IL-10 is a cytokine with multiple effects in immune regulation and inflammation. Besides, it downregulated Th1 cytokines, class II MHC antigens, and…
The cytokine IL-10 promotes immune homeostasis via multiple mechanisms. It includes suppressing inflammatory cytokine production by innate immune cells and by promoting regulatory T cell (Treg) function. Loss-of-function mutations in…
G protein-coupled receptors (GPCRs) are also known as 7TM receptors due to their transmembrane domains. they constitute the largest superfamily of receptors for signaling molecules, ligands Many ligands, including hormones,…