Omaveloxolone (RTA 408) is an agent for Friedreich's Ataxia. And it acts through a combination of activation of the antioxidative transcription factor Nrf2 and inhibition of the pro-inflammatory transcription factor…
Spleen tyrosine kinase (Syk) is a 72 kDa non-receptor tyrosine kinase. Specifically, Syk is activated by binding the tandem SH2 domain to the immune receptor tyrosine activation motif (ITAM). Syk…
Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Abnormal dopamine receptor signaling and dopaminergic nerve function can lead to…
Inflammasomes are protein complexes that are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18.…
Caspase is a family of protease that plays an important role in programmed cell death. Specifically, caspase also has other definite roles in programmed cell death, such as apoptosis and…
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease of the central nervous system (CNS) and is a leading cause of chronic neurological disability. The most remarkable hallmarks of MS are…
In the NLR family, the NLRP3 inflammasome plays essential roles in the maturation and production of IL-1β and IL-18. Dysregulation of inflammasome and IL-1β affects the pathogenesis of many human…
The inflammasomes are protein complexes. The innate immune sensors, including NOD-like receptor (NLR) family members (NLRP1, NLRP3, and NLRC4) as well as other non-NLR receptors form them. Upon activation, the…