Necroptosis is a classical mode of cell death co-regulated by RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL). Necroptosis begins with the activation of death receptors, such as tumor…
RIPK1 (receptor-interacting protein kinase 1) is a serine/threonine protein kinase. It also is a key regulator of programmed cell necrosis (necroptosis). RIPK1 is closely related to the occurrence and development…
Necrosis is the death of cells and tissues. The kinase activity of receptor-interacting protein kinase 1 (RIP1/RIPK1) and/or RIP3/RIPK3 mediates this regulated form of necrosis. These results suggest RIP1 and…
RIP1 is a crucial adaptor kinase on the crossroad of stress-induced signalling pathways and a cell's decision to live or die. Particularly, RIP1 acts in multiple signaling pathways to regulate…
Necroptosis is a programmed form of necrosis, or inflammatory cell death. Especially, necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis and necrosis. Necroptosis is triggered…
Necroptosis is a programmed necrosis or inflammatory cell death. It is different from apoptosis. Necroptosis is due to cellular damage or infiltration by pathogens. It is a component of inflammatory…
Necroptosis is an alternative form of programmed cell death that is triggered when apoptosis is inhibited. Apoptosis is characterized by a requirement for caspases. Receptor-interacting protein kinase 3 (RIP3 or RIPK3)…