HIV protease, a homodimeric aspartyl protease, is an essential component of the Human Immunodeficiency Virus genome. HIV protease is responsible for cleaving the Gag and Gag-Pol polyproteins in a late…
Thiol protease is a kind of proteolytic enzyme. Thiol protease catalyzes hydrolysis of peptide bond by sulfhydryl group with sulfhydryl group in the active center. Interestingly, thiol proteases, also known…
Gingipains are a family of proteases secreted by Porphyromonas gingivalis. Members of gingipains (family C25) strictly cleave peptide bonds with either Arg-Xaa or Lys-Xaa at the cleavage site, and Arg-gingipain…
Hepatitis C virus (HCV) is a human pathogen with high morbidity. The HCV NS3/4A protease is essential for viral replication and is one of the top three drug targets. BMS-986144…
The human immunodeficiency viruses (HIV) are two species of Lentivirus that infect humans. It causes acquired immunodeficiency syndrome (AIDS). Besides, AIDS is a condition in which progressive failure of the…