In this article, we will introduce a selective, reversible, and orally active BTK inhibitor, BIIB068. As a selective inhibitor, BIIB068 exhibits an IC50 of 1 nM and a Kd of 0.3 nM against BTK….
GPR84 is a de-orphanized member of the G-protein coupled receptor (GPCR) family, it can recognize medium-chain fatty acids. GPR84 plays an important role in inflammation. In this article, we will…
Oncogenic c-Ros oncogene1 (ROS1) fusion kinases have been identified in a variety of human cancers and are attractive targets for cancer therapy. The MET/ALK/ROS1 inhibitor has demonstrated promising clinical activity…
NADPH oxidase (NOX) enzymes are major sources of reactive oxygen species (ROS). In particular, NOX mediates signaling events in a variety of physiological processes, such as hormone biosynthesis, cell signaling,…