![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/11/SEW2871-is-a-Highly-Selective-and-Orally-Active-S1P1-Agonist-2019-11-07.jpg)
G protein-coupled receptors (GPCRs) are also known as 7TM receptors due to their transmembrane domains. they constitute the largest superfamily…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/10/VPC-23019-is-a-Competitive-Antagonist-of-S1P1-and-S1P3-Receptors-and-an-Agonist-of-S1P4-and-S1P5-Receptors-2019-10-12.jpg)
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator. S1P evokes a variety of cellular responses by stimulation of five members of…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/09/ASP1126-is-an-Orally-ActiveS-1P-Agonist-With-a-Favorable-Safety-Profile-2019-09-21.jpg)
Immunosuppressants that prevents acute rejection has dramatically improved graft survival in organ transplantation. For instance, calcineurin inhibitors (CNIs) improve the…