G protein-coupled receptors (GPCRs) are also known as 7TM receptors due to their transmembrane domains. they constitute the largest superfamily of receptors for signaling molecules, ligands Many ligands, including hormones,…
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator. S1P evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene receptor family. The recent development…
Immunosuppressants that prevents acute rejection has dramatically improved graft survival in organ transplantation. For instance, calcineurin inhibitors (CNIs) improve the survival of patients receiving transplants. However, CNIs also cause adverse…