Coronaviruses are a diverse group of viruses infecting many different animals, and they can cause mild to severe respiratory infections. In 2002 and 2012, respectively, two highly pathogenic coronaviruses with…
HIV protease, a homodimeric aspartyl protease, is an essential component of the Human Immunodeficiency Virus genome. HIV protease is responsible for cleaving the Gag and Gag-Pol polyproteins in a late…
Serine proteases are the largest class of mammalian proteases. Serine proteases exist in all kingdoms of cellular life as well as many viral genomes. Over one-third of all known proteolytic…
HIV protease is a homodimeric aspartyl protease. It is worth noting that, HIV protease is crucial for the viral life-cycle. Specifically, HIV protease cleaves proviral polyproteins, hence creates mature protein…
SARS-CoV is the coronavirus (CoV) that causes severe acute respiratory syndrome (SARS), including not only SARS, but also Middle East respiratory syndrome (MERS) and SARS-CoV-2 (the cause of COVID-19). The…
Coronaviruses (CoV) are large plus-strand RNA viruses. They cause medical disorders such as the common cold, lower respiratory tract infections, and diarrhea. The SARS-CoV genome encodes a large polyprotein. Two…
The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. Specifically, the complement system is a complex network, including the interaction…