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Tag: Ubiquitination

GS143 is a Selec­tive IκBα Ubiquitination Inhibitor

2020-09-01 Edward Jenner

GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. Firstly, when GS143…

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Posted in: Asthma, Bronchial Airway Infection, Cancer Immunology, Inflammation Filed under: IκB, NF-κB, p53, Th2, Ubiquitination, β-catenin

BRD5529 is a Selective CARD9–TRIM62 PPI Inhibitor

2019-11-18 Edward Jenner

The allele family CARD9 variant relates to increased or protected risk of inflammatory bowel disease (IBD). Moreover, the susceptible variant…

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Posted in: Colitis, Inflammation, Ulcerative Colitis Filed under: CARD9, TRIM62, Ubiquitination
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5-HT Anti-Inflammatory Anti-Tumor Antibacterial Antimalarial Antitumor Antiviral Apoptosis Autophagy Breast Cancer Chemokines COPD COVID-19 Cytokine EGFR HBV HCV HDAC HIV IFN IL-6 IL-17 Infection Integrin Interferon Interleukin IPF JAK Leukemia Low Toxicity Multidrug Resistance Necroptosis NF-κB p38 MAPK PPI Proteasome RIPK STAT STING T Cell Th17 TLR TNF TNF-α α4β1
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