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T16A(inh)-C01 is an Inhibitor of TMEM16A (ANO1)

2022-08-11 Edward Jenner

Calcium-activated chloride channels (CaCCs) are always expressed in epithelial and nonepithelial cells. They are involved in epithelial fluid secretion, sensory…

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Posted in: hypertension, Inflammation, Innate Immune Filed under: Asthma, CaCCs, hypertension, Pain, secretory diarrheas, T16Ainh-A01, TMEM16A, tracheomalacia

Bepotastine is a Selective and Orally Active Second-generation Histamine H1 receptor Antagonist

2022-08-09 Edward Jenner

Atopic dermatitis is a chronically relapsing inflammatory skin disease. The characteristics of atopic dermatitis are eczema and even pruritus. The…

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Posted in: Atopic Dermatitis, Autoimmune Disorders Filed under: allergic conjunctivitis, allergic rhinitis, Antihistamine, Atopic Dermatitis, Bepotastine, inflammatory skin disease, pruritus

Perindoprilat (S 9780) is an ACE inhibitor for Hypertension Research

2022-08-07 Edward Jenner

Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 value ranging from 1.5 nM. Besides, Perindoprilat shows an affinity for…

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Posted in: Immunology, Immunotherapy, Inflammation Filed under: Angiotensin II, hypertension, Perindoprilat, renoprotection

Flavoxate is a Potent and Competitive PDE inhibitor

2022-08-06 Edward Jenner

Phosphodiesterases (PDEs) are enzymes that catalyze the hydrolysis of the 3′ cyclic phosphate bond of cyclic nucleotides. PDEs can break…

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Posted in: Analgesia, Inflammation Filed under: Overactive Bladder, Urinary Tract Infection

Loxoprofen is an Orally Active and Non-selective COX Inhibitor

2022-08-02 Edward Jenner

Cyclooxygenase (COX), also called prostaglandin endoperoxide synthase, is an oxidoreductase enzyme, including two isoforms: COX-I and COX-II. It acts in…

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Posted in: Inflammation Filed under: Cyclooxygenase, HUVEC, Loxoprofen, NSAID

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  • T16A(inh)-C01 is an Inhibitor of TMEM16A (ANO1) 2022-08-11
  • Bepotastine is a Selective and Orally Active Second-generation Histamine H1 receptor Antagonist 2022-08-09
  • Perindoprilat (S 9780) is an ACE inhibitor for Hypertension Research 2022-08-07

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