Interleukins are a group of cytokines, a secreted proteins and signaling molecules. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a…
Hepatitis C virus (HCV) is a positive-strand RNA virus grouped in the genus Hepacivirus within the family Flaviviridae. HCV is classified into at least 6 genotypes (gt), and its error-prone…
Neutropenia is usually caused by the myelosuppressive chemotherapy, and along with severe neutropenia. Meanwhile, G-CSF is a hormone that stimulates the production, differentiation, proliferation and activation of neutrophils from the…
Remibrutinib is a potent and orally active BTK inhibitor for Chronic urticaria (CU) research.
On November 15, 2023, the U.S. Food and Drug Administration has approved Defencath (taurolidine and heparin) catheter lock solution (CLS). CLS can reduce the incidence of catheter-related bloodstream infections in…
Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors.…
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory…
Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging and in chronic kidney disease (CKD). The US Centers for Disease Control and Prevention project that 47% of…
Duchenne muscular dystrophy (DMD) is a genetic muscle disease. And The feature is contraction-induced myofibre injury and inflammation. Besides, researchers found that NF-κB signaling is active in dystrophin deficient muscle.…
Factor XIa (FXIa) is a serine protease involved in the coagulation cascade. Moreover, FXI knockout mice were found to be protected from arterial and venous thrombosis. Therefore, that FXIa inhibition…