Kinases typically integrate signaling events down-stream of multiple cytokine receptors. Hence, kinase inhibitors distinguish themselves from cytokine-targeted biologicals by their…
Lp-PLA2 (Lipoprotein-associated phospholipase A2) is a calcium-independent serine lipase of 50-kDa that hydrolyzes the acetyl group at the sn-2 position…
p38 mitogen-activated protein kinase (MAPK) plays a key role in cellular response, proliferation, survival, cell cycle and cancer migration. Moreover, the…
cPLA2α is an intracellular calcium dependent PLA2. It is expressed in a wide variety of tissues and cells. Firstly, cPLA2α…
Neurokinin 3 receptor (NK3R) is the most selective of the tachykinin receptors, with highly preferential binding and activation by its…