TAK-779 is an Antagonist of CCR5 and CXCR3, with Anti-HIV-1 Effect
Nowadays, people are no strangers to AIDS. It is a kind of infectious disease caused by HIV. The latter primarily acts on human immune system, like CD4+ T cells. These…
Nowadays, people are no strangers to AIDS. It is a kind of infectious disease caused by HIV. The latter primarily acts on human immune system, like CD4+ T cells. These…
In our previous blogs, we have mentioned autoimmune disease many times. There are various types of autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and psoriasis. The…
Influenza is one of the major plagues worldwide. Particularly, Influenza is a viral infection that attacks our respiratory system. Influenza A virus remains a major public health concern, both in…
Chemokines and their receptors participate a variety of immune responses to infection, inflammation, and tissue repair. Among them, CXCR4 is a chemokine receptor that has one known natural ligand, CXCL12…
As early as in 1998, the researchers have discovered the selective and non-peptide CXCR2 antagonist SB225002. CXCR1 and CXCR2 are two chemokine receptors in Neutrophils. They play an important role…
Multiple sclerosis is a demyelinating disease with damaged insulating covers of nerve cells in the brain and spinal cord. It is a kind of inflammatory disease, affects the central nervous…
NF-κB is a transcription factor with heterodimer or homodimer form of rel family proteins such as RelA (p65), RelB, cRel, p50 and p52. NF-κB binds to inhibitory κB (IκB) proteins…
Various types of cytokinesuchemokines react with their receptors. They transduce extracellular signals into intracellular response through a mitogen-activated protein kinase (MAPK) signalling cascade. Furthermore, p38 MAPK signalling might play an…
Currently, a void exists for serine/threonine protein kinase inhibitor drugs and central nervous system indications. Stress kinases are of special interest in neurological and neuropsychiatric disorders, because of their involvement…
The 5-lipoxygenase (LOX) pathway plays an important role in the pathophysiology of asthma. 5-LOX is an important arachidonic acid-metabolizing enzyme producing leukotrienes and other proinflammatory lipid mediators. Moreover, it has…