SYN1143 is a Selective Dual Inhibitor of c-Met/RON
Receptor d'origin nantais (RON) is a receptor tyrosine kinase (RTK), which is usually expressed at a low level in epithelial cells. In terms of source and function, it is closely…
Receptor d'origin nantais (RON) is a receptor tyrosine kinase (RTK), which is usually expressed at a low level in epithelial cells. In terms of source and function, it is closely…
SW106065 inhibits the growth of all available in vitro models of malignant peripheral nerve sheath tumors and human MPNST cell lines while remaining non-toxic to normally-dividing Schwann cells or mouse…
IRAK4 (interleukin-1 receptor-associated kinase 4) is a protein kinase in the IRAK family. Specifically, IRAK-4 is relevant to signal transduction of innate immune response from toll-like receptors. It also supports…
Ovarian cancer is one of the leading causes of death in women with gynecological cancers in the United States. About 70% of ovarian cancer cases are diagnosed at a late…
Caspase is a family of protease that plays an important role in programmed cell death. Specifically, caspase also has other definite roles in programmed cell death, such as apoptosis and…
Lysophosphatidic acid (LPA) is a phospholipid growth factor that stimulates proliferation, chemotaxis, cation currents, and K+ currents in retinal pigment epithelial (RPE) cells. In particular, LPA is an extracellular signaling…
ULK1/2 is an important protein in autophagy for mammalian cells and homologous Atg1 in yeast. Specifically, it is part of the ulk1 complex and is in the early stages of…
Mitosis is an attractive target for selective anticancer treatment. Mitotic kinases, including CDKs, AURKs, and PLK1, associate with tumor progression and prognosis. However, these agents are cytotoxicity to healthy cells. inhibitors against…