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KRN5 is a Nuclear Factor of Activated T Cells 5 (NFAT5) Suppressor
Nuclear factor of activated T cells 5 (NFAT5) participates in the pathogenesis of various human diseases, including cancer and arthritis. However, there are no therapeutic drugs that inhibit the activity…
PF-06795071, a Potent Covalent MAGL Inhibitor
Neuroinflammation is an inflammatory response within the brain or spinal cord. The production of cytokines, chemokines, reactive oxygen species, and secondary messengers mediate this inflammation Neuroinflammation occurs as a consequence…
JTE-952 is A Selective Type II CSF-1R/cFMS Inhibitor
The colony stimulating factor-1 receptor (CSF-1R or cFMS) is a type III receptor tyrosine kinase. It activates via binding CSF-1 and IL-34, stimulating differentiation, proliferation, survival and migration of monocyte-macrophage…
Halofuginone Attenuates Osteoarthritis
Osteoarthritis is one of the most frequent chronic diseases. For instance, Osteoarthritis is a major source of pain. The epidemiology of the disorder is complex and multi-factorial. Interestingly, osteoarthritis is…
TAK-828F is a Potent and Selective RORγt Inverse Agonist
The retinoic acid-related orphan receptor (ROR) is a subclass of orphan nuclear receptors. There are three subtypes, including RORα, RORβ, and RORγ. Importantly, RORγt is a master regulator for differentiation…
Abrocitinib, a Selective JAK1 Inhibitor Against Autoimmune Disease
Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases. It transduces cytokine-mediated signals via the JAK-STAT pathway. Four members are in JAK family, they are JAK1, JAK2, JAK3,…
PXS-5153A is A Lysyl Oxidase Like 2/3 Enzymatic Inhibitor
The leading feature of the progressive disease fibrosis is the excessive deposition of extracellular matrix and crosslinked proteins. In particular, the two proteins, collagen and elastin, lead to tissue stiffening…
JNJ4796, An Oral Influenza Virus Inhibitor, Mimics the Functionality of bnAbs
The World Health Organization estimates that influenza epidemics cause approximately 3 million to 5 million cases of severe illness. What’s worse, up to 650,000 people died worldwide each year. Recently,…