J-113863 is a CCR1 Antagonist for Rheumatoid Arthritis Treatment
The CC-type chemokine receptor 1 (CCR1) is a chemokine receptor of significant importance in human health. CCR1 is a protein that in humans is encoded by the CCR1 gene. Moreover,…
The CC-type chemokine receptor 1 (CCR1) is a chemokine receptor of significant importance in human health. CCR1 is a protein that in humans is encoded by the CCR1 gene. Moreover,…
Ionotropic (ligand-gated ion channel), P2X, and metabotropic P2Y receptors belong to P2 receptors. Up to now, eight subtypes of human P2Y receptors are P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11-14. P2…
Adenosine triphosphate (ATP) is an important neurotransmitter implicated in various physiological and pathophysiological roles. It acts through different subtypes of purinergic receptors. There are seven members in the P2X family…
GPR84 is a de-orphanized member of the G-protein coupled receptor (GPCR) family, it can recognize medium-chain fatty acids. GPR84 plays an important role in inflammation. In this article, we will…
Staphylococcus aureus is a major bacterial human pathogen that causes a wide variety of clinical manifestations. Staphylococcus aureus is the leading cause of infections worldwide, and methicillin-resistant strains (MRSA) are…
Glucocorticoids (GCs) are the most commonly used anti-inflammatory and immunosuppressive drugs. GCs possess outstanding therapeutic effects, however, severe and sometimes irreversible side effects always accompany them. Therefore, it is urgent…
Polyunsaturated fatty acids (PUFAs) play key roles in the immune response. They act as substrates for the synthesis of lipid second messengers involved in cell activation. It includes eicosanoids and…
Cyclooxygenase (COX) -2 is an inducible form of COX, and it involves in inflammation. In addition, Malignant mesothelioma (MM) is a fatal malignancy with an estimated incidence of 3,000 cases…
Matrix metalloproteinases (MMPs) are a family of Zn2+-binding, Ca2+-dependent endopeptidases. They play a prominent role in the physiological and pathological degradation of mammalian extracellular matrix (ECM). The activity of MMPs…
K2P (KCNK) potassium channels belong to the voltage-gated ion channel (VGIC) superfamily. K2P channels can generate leak currents and stabilize the resting membrane potential of excitable cells. In addition, these…