Duchenne muscular dystrophy (DMD) is a genetic muscle disease. And The feature is contraction-induced myofibre injury and inflammation. Besides, researchers found that NF-κB signaling is active in dystrophin deficient muscle.…
Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease,…
ETA and ETB Receptor are isoforms of endothelin receptor. The ETA receptors on vascular smooth muscle cells mediate vasoconstriction. Otherwise, ETB Receptor is present in both endothelial and vascular smooth…
Aryl Hydrocarbon Receptor (AhR or AHR) is a cytoplasmic receptor and transcription factor that belongs to the family of basic helix-loop-helix transcription factors. The AhR is activated or inhibited by…
Arachidonic acid 15 lipoxygenases (ALOX15) is a key enzyme relevant to the synthesis of specific resolution media (SPM). Specifically, it includes lipoxygenase (LXs), decomposers (Rvs), protective elements, and maresins. 15-LOX-1,…
IL-6 (Interleukin 6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. Besides, IL-6 signals through a cell-surface type I cytokine receptor complex consisting of…
Histamine H4 Receptor (H4R) is a member of the G protein-coupled receptor superfamily. Besides, H4R involves in mediating eosinophil shape change and mast cell chemotaxis. Importantly, H4R mRNA and protein…
eIF2 (eukaryotic initiation factor 2), an eukaryotic initiation factor, is an essential factor for protein synthesis. eIF2 mediates the binding of tRNAiMet to the ribosome in a GTP-dependent manner. And…
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA, cytokine production and cell survival. Moreover, NF-κB is present in virtually all…
RIPK1 (receptor-interacting protein kinase 1) is a serine/threonine protein kinase. It also is a key regulator of programmed cell necrosis (necroptosis). RIPK1 is closely related to the occurrence and development…