Alzheimer’s disease (AD) is a chronic neurodegenerative disease that usually starts slowly and gradually worsens over time. In this study, researchers have identified CMS-121 that is very neuroprotective. In HT22…
COX-2 is the more important source of prostanoid formation in inflammation and in proliferative diseases. In particular, COX-2 prefers prostaglandin I synthase and the microsomal PGES isozymes. DuP-697 is an…
Inflammatory pain is typically treated with non-steroidal anti-inflammatory drugs. However, prolonged use of non-steroidal anti-inflammatory drugs associates with significant side-effects. Fatty acid-binding proteins (FABPs) are a family of small, highly…
Calcium sensitizer agents are a class of inotropic agents in the treatment of decompensated heart failure. Levosimendan is a short half-life calcium sensitizer used as pharmacological inotropic support in acute…
MAPKs include many serine-threonine kinases. One of the major MAPK cascades is p38 MAPKs. p38 MAPK can serve as a potential therapeutic target for the treatment of not only inflammatory…