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Inflammation Inflammatory

Vamorolone is a Steroidal Anti-inflammatory Agent for Duchenne Muscular Dystrophy Research

Edward Jenner 2023-11-17

Duchenne muscular dystrophy (DMD) is a genetic muscle disease. And The feature is contraction-induced myofibre injury and inflammation. Besides, researchers found that NF-κB signaling is active in dystrophin deficient muscle.…

Immunity Immunology

ER-27319 is a Syk Inhibitor for Inflammation Diseases Research

Edward Jenner 2023-09-14

Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease,…

Cardiovascular Inflammation

BQ-3020 is a Selective ETB Receptor Agonist for Cardiovascular Disease Research

Edward Jenner 2023-09-12

ETA and ETB Receptor are isoforms of endothelin receptor. The ETA receptors on vascular smooth muscle cells mediate vasoconstriction. Otherwise, ETB Receptor is present in both endothelial and vascular smooth…

Atopic Dermatitis Psoriasis

Tapinarof is an AhR Agonist for Skin Inflammation Research

Edward Jenner 2023-07-21

Aryl Hydrocarbon Receptor (AhR or AHR) is a cytoplasmic receptor and transcription factor that belongs to the family of basic helix-loop-helix transcription factors. The AhR is activated or inhibited by…

Inflammatory Neuroimmunology Neurological Disease

ThioLox is a Competitive 15-LOX-1 Inhibitor with Anti-inflammatory and Neuroprotective Property

Edward Jenner 2023-05-10

Arachidonic acid 15 lipoxygenases (ALOX15) is a key enzyme relevant to the synthesis of specific resolution media (SPM). Specifically, it includes lipoxygenase (LXs), decomposers (Rvs), protective elements, and maresins. 15-LOX-1,…

Immune Inflammation

Olamkicept is a Selective Inhibitor of sIL-6R/IL-6 Complex

Edward Jenner 2023-03-28

IL-6 (Interleukin 6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. Besides, IL-6 signals through a cell-surface type I cytokine receptor complex consisting of…

Inflammatory Nociceptive

A-943931 is a Potent and Selective H4R Antagonist

Edward Jenner 2023-02-20

Histamine H4 Receptor (H4R) is a member of the G protein-coupled receptor superfamily. Besides, H4R involves in mediating eosinophil shape change and mast cell chemotaxis. Importantly, H4R mRNA and protein…

Inflammation Rheumatoid Arthritis

Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation

Edward Jenner 2023-01-04

eIF2 (eukaryotic initiation factor 2), an eukaryotic initiation factor, is an essential factor for protein synthesis. eIF2 mediates the binding of tRNAiMet to the ribosome in a GTP-dependent manner. And…

Diabetic Complication Osteoporosis

Dehydromiltirone is a Diterpenoid Quinone with an Anti-Inflammatory Effect

Edward Jenner 2022-12-29

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA, cytokine production and cell survival. Moreover, NF-κB is present in virtually all…

Immunology

RI-962 is a Selective RIPK1 Inhibitor for Inflammatory Diseases Research

Edward Jenner 2022-12-17

RIPK1 (receptor-interacting protein kinase 1) is a serine/threonine protein kinase. It also is a key regulator of programmed cell necrosis (necroptosis). RIPK1 is closely related to the occurrence and development…

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You Missed

Inflammation Ulcerative Colitis

Mirikizumab is a Humanized IgG4 mAb for Ulcerative Colitis Research

Hepatitis Hepatitis C Virus

Grazoprevir is a Hepatitis C virus NS3/4A Protease Inhibitor for Infection Research

Breast cancer Infection

Efbemalenograstim alfa is a Recombinant Fusion Protein for Neutropenia Research

Cancer Chronic Urticaria Inflammatory Uncategorized

Remibrutinib is an Orally Active BTK Inhibitor for Chronic Urticaria Research

Immune System Research

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