Poly (ADP ribose) polymerase (PARP) is a family of proteins involved in many cellular processes, such as DNA repair, genomic stability, and programmed cell death. Specifically, PARP consists of four…
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key node in innate inflammatory signaling. It is also directly downstream of the Toll-like receptors (TLRs) and interleukin-1 (IL-1) family of receptors. Besides,…
Tumor angiogenesis plays an essential role in carcinogenesis, cancer progression, and metastasis. The inflammation is a key feature of the environment within and around tumors. Some studies indicate that the…
Alzheimer’s disease (AD) is a chronic neurodegenerative disease that usually starts slowly and gradually worsens over time. In this study, researchers have identified CMS-121 that is very neuroprotective. In HT22…
COX-2 is the more important source of prostanoid formation in inflammation and in proliferative diseases. In particular, COX-2 prefers prostaglandin I synthase and the microsomal PGES isozymes. DuP-697 is an…