Neutrophil granulocytes play an important role in regulating and fine-tuning inflammatory reactions. FPRs can recognize danger signals during microbial infections, inflammation, cancer, and tissue injury. In general, FPR recognizes formyl…
Toll-like receptor (TLR) family proteins belong to PRRs. They play a crucial role in the initiation of the hosts’ immune responses, linking innate immunity and adaptive immunity. TLRs recruit a…
MyD88 is an adaptor protein. It plays an essential role in the intracellular signaling elicited by IL-1R and several TLRs. MyD88 has a Toll/IL-1R translation initiation region (TIR) domain heterodimerize…
In cancer, CG-200745 is a novel and potent hydroxamate-based pan-HDAC inhibitor. Moreover, another study from Hong Sang Choi demonstrated that CG200745 attenuates renal fibrosis in obstructive kidney disease. Epigenetic modifications…
The serine hydrolases monoacylglycerol lipase (MAGL) is responsible for degrading 2-arachidonoyl glycerol (2-AG). And the fatty acid amide hydrolase (FAAH) degrades N-arachidonoyl ethanolamine (anandamide or AEA). They are endogenous agonists…