For individuals with weakened immune systems, fungal infections with high mortality rates could be life-threatening. Although there are many antifungal agents already, drug resistance is still a critical issue. For…
Antifungal agents are drugs that selectively eliminate fungal pathogens from the host with minimal toxicity. Meanwhile, bacteria are prokaryotes and therefore provide many structural and metabolic targets that differ from…
Muramyl dipeptide (MDP) can exert an adjuvant activity on antibody formation and cell-mediated immunity in experimental animals. Furthermore, MDP also can augment the activities of macrophages. On the basis of…
Echinococcins are a class of antifungal drugs. These drugs inhibit glucan synthase, which is responsible for synthesis β1-3 linked glucans. Meanwhile, echinococcin inhibits 1,3 through noncompetitive inhibition- β Glucan synthase…
Melittin is the main component of bee venom and the main pain-causing substance that can cause allergic reactions. When injected into animals and humans Melittin causes nociception and activates pain…
Antifungal drugs are used to treat fungal infections. Fungi causes a variety of diseases in humans, from allergic syndrome to superficial, disfigured and life-threatening invasive fungal disease (IFD). Specifically, antifungal…
Mefentrifluconazole is a novel azole derivative. Additionally, it acts as an agrochemical broad-spectrum antifungal agent. Furthermore, Mefentrifluconazole is a potent, selective, and orally active fungal CYP51 (Kd=0.5 nM) inhibitor. However, it shows less…
Inhalation and deposition of Aspergillus conidia in the lung is the most common route of infection for patients. Existing antifungal medicines are predominantly in orally or systemically. These frequently exploited routes…
iKIX1 is an anti-fungal agent and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro. In HepG2 cells, iKIX1 inhibits cell growth in a concentration-dependent manner in the presence of…
Onychomycosis is an infection of the nail plate that is prevalent among the ageing population. Onychomycosis is difficult to treat with low initial cure rates, high rates of relapse, and…