Sigma Ligands has cytotoxic activity in vitro and is able to induce ceramide/caspase-independent apoptosis. In addition, these ligands down-regulate P-glycoprotein (P-gp) mRNA levels in some mouse and human models. In…
Rheumatoid arthritis (RA) is a kind of destructive systemic autoimmune disease. Many different inflammatory cells invade the joint synovium. In addition, the destruction of cartilage and bone is due to…
Mammalian cell division involves an orderly progression through four distinct phases: G1 (growth phase 1), S (DNA synthesis), G2 (growth phase 2), and M (mitosis). During the G1 phase, cells…
Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from an ε-N-acetyl-lysine amino acid on a histone. Specifically, selective HDAC inhibitors are as a potential anti latent…
Many malignancies, particularly leukemias, are associated with aberrant recruitment of histone deacetylases (HDACs) or with mutations in histone acetyltransferases such as EP300. In addition, Histone acetylation plays a key role…