Anti-arthritis drugs are used to relieve or prevent arthritis symptoms (such as joint pain and Joint stiffness). Specifically, the impact of rheumatism on fertility and reproduction may be significant. Individuals…
PI3Kδ is a lipid kinase mainly expressed in hematopoietic cells and responsible for key signal transduction in cells of the immune system. Antigens can acutely activate PI3Kδ in B and…
JNJ-61803534 is a potent and orally active RORγt inverse agonist. JNJ-61803534 exhibits anti-inflammatory activity. It inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions. JNJ-61803534 (1 nM-1…
eIF2 (eukaryotic initiation factor 2), an eukaryotic initiation factor, is an essential factor for protein synthesis. eIF2 mediates the binding of tRNAiMet to the ribosome in a GTP-dependent manner. And…
The colony stimulating factor-1 receptor (CSF-1R or cFMS) is a type III receptor tyrosine kinase. It activates via binding CSF-1 and IL-34, stimulating differentiation, proliferation, survival and migration of monocyte-macrophage…