Integrin αvβ6 is a member of the arginyl glycyl aspartate (RGD) subfamily of heterodimer transmembrane glycoprotein receptor 9. Specifically, αvβ6 is an epigenetic integrin. It is the receptor of extracellular…
Lymphocyte function-associated antigen 1 (LFA-1; αLβ2) is a key T cell integrin, which plays an important role in regulating T cell activation and migration. Specifically, LFA-1 belongs to the integrin…
Integrin α4β1 (VLA-4) promotes the immune system's inflammatory response by helping white blood cells move to tissues that need inflammation. Specifically, VLA-4 is a key factor in cell adhesion. Besides,…
Integrin α4β1 is an integrin dimer and is composed of CD49d (alpha 4) and CD29 (beta 1). Specifically, integrin α4β1 promotes the inflammatory response of the immune system by helping white blood cells move…
In molecular biology, CD18 (integrin beta chain 2) is an integrin beta chain protein encoded by the human itgb2 gene. Specifically, the lack of CD18 expression can lead to adhesion…
Hematopoietic stem and progenitor cells (HSPCs) reside is in a specialized microenvironment. It also refers to the stem cell niche, which regulates critical HSPC processes, such as self-renewal and differentiation.…
Very Late Antigen-4 (VLA4 or CD49d/CD29) is aα4β1 integrin with a pivotal role in controlling immune cell migration into inflamed tissue. Especially, BIO1211 acts as a probe to assess α4β1…
Hematopoietic stem and progenitor cells (HSPCs) reside means a specialized microenvironment, which regulates self-renewal and differentiation of HSPCs. Hematopoiesis in the adult mouse often exists in spleen and bone marrow.…
Asthma is an inflammatory disorder of the airways. Moreover, asthma is a long-term disease of the lungs. The features of asthma pathophysiology are the production of cytokines and infiltration of…
Integrins are cell surface protein receptors with α and β subunits. They participate in multiple cellular functions such as adhesion and anchoring to extracellular matrix, transducing growth factor signals. Emerging…