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Tag: Interleukin

PF-06426779 is a Selective IRAK4 inhibitor

2020-12-09 Edward Jenner

IRAK4 (interleukin-1 receptor-associated kinase 4) is a protein kinase in the IRAK family. Specifically, IRAK-4 is relevant to signal transduction…

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Posted in: Inflammation Filed under: Interleukin, IRAK4

SP-100030 is a Potent NF-κB and Activator Protein-1 (AP-1) Inhibitor

2020-10-01 Edward Jenner

Nuclear factor-κB (NF-κB) represents a family of inducible transcription factors. The transcription factor NF-κB regulates multiple aspects of innate and…

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Posted in: Arthritis, Collagen-Induced Arthritis, Inflammation Filed under: AP-1, Interleukin, Jurkat, NF-κB, TNF-α

R243 Inhibits CCL1/CCR8 Interaction, with Antinociceptive and Anti-inflammatory Effects

2020-06-17 Edward Jenner

Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein encoded by the CCR8 gene in the human…

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Posted in: Inflammation Filed under: CCL1, CCR8, Interleukin, TNF-α

CU-T12-9 is a Specific TLR1/2 Agonist

2020-01-01 Edward Jenner

Toll-like receptors belong to a family of pattern recognition receptors, regulate innate immunity and subsequent adaptive immune responses. TLRs can…

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Posted in: Inflammation Filed under: iNOS, Interleukin, TLR, TNF

Selgantolimod is an Orally Active and Selective TLR8 Agonist for HBV and HIV for Treatment

2019-12-29 Edward Jenner

Toll-like receptors (TLRs) are type I membrane glycoproteins. They contain intracellular Toll–IL-1 receptor homology (TIR) domains. TLRs recognize a wide…

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Posted in: HBV, HIV Filed under: Antiviral, Interleukin, TLR8

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