Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease,…
Autoimmune diseases, including rheumatoid arthritis (RA) and immune thrombocytopenia (ITP), are caused by aberrant immune responses. ITP is an autoimmune bleeding disorder in which opsonization by platelet-specific autoantibodies results in…
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase. Syk plays an important role in allergic diseases and inflammation. Thus, Syk is an attractive target for therapeutic kinase inhibitors. This…