MLS-573151 is a Selective GTPase Cdc42 Inhibitor
Cdc42 is a protein involved in cell cycle regulation. Specifically, human Cdc42 is a small GTPase of the Rho family, which regulates the signaling pathways controlling various cell functions. Rho…
Cdc42 is a protein involved in cell cycle regulation. Specifically, human Cdc42 is a small GTPase of the Rho family, which regulates the signaling pathways controlling various cell functions. Rho…
The second messengers cyclic AMP (cAMP) and cyclic GMP (cGMP) regulate a myriad of processes. They include cell proliferation, differentiation, apoptosis, inflammation, hormone secre-tion, muscle contraction, and cognitive functions. Intracellular…
The somatostatin receptor is the receptor of the ligand somatostatin, especially in the postsynaptic response to the costimulation/activation of the NMDA receptor. Specifically, somatostatin is a small neuropeptide related to…
The adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a central regulator of metabolic pathways. Increasing AMPK activity is an attractive therapeutic target. Fbxo48 is an orphan ubiquitin E3 ligase subunit…
G protein-coupled receptors (GPCRs) are versatile membrane proteins. GPCRs initiate cascades of intracellular signaling events in response to an extraordinary array of extracellular signals. TRV056 is a Gq-biased ligand of…
Vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. Calcitriol (the active form of vitamin D, 1,25-(OH)2 vitamin D3) binds to VDR and then…
The complement system represents an innate immune mechanism of host defense. The complement system has three effector arms, the C3a receptor, the C5a receptor (C5aR), and the membrane attack complex.…
Naive CD4+ T helper (Th) cells can differentiate into two distinct subsets, Th2 and Th1. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, and control humoral immunity against parasites and…