Antibiotics are antibacterial substances that are active against bacteria. Antibiotics have an effect on treating and preventing such infections. Meanwhile, they can kill or inhibit the growth of bacteria. A limited number of antibiotics also have anti protozoan activity. Nonetheless, macrolides are a class of antibiotics, including Erythromycin, Roxithromycin, Azithromycin, and Clarithromycin. Macrolide antibiotics are used to fight major respiratory diseases caused by Gram-positive pathogens and harsh Gram-negative pathogens.

Importantly, macrolide antibiotics inhibit bacterial protein synthesis by interfering with ribosome function. Macrolide antibiotics contain a large macrolide ring to which one or more deoxysugars can be attached. These antibiotics inhibit the biosynthesis of bacterial proteins by reversibly binding with subunit 50s of bacterial ribosome and preventing the translocation of peptidyl tRNA. Particularly, macrolides interact with the 50S ribosomal subunit of bacilli, thereby inhibiting protein synthesis and preventing bacterial replication. Low dose and long-term treatment of macrolides is an effective treatment for a wide range of respiratory diseases and in several animal models of lung injury. Today, we will introduce a macrolide antibiotic, Oleandomycin.

Oleandomycin is a Macrolide Antibiotic.

First of all, Oleandomycin is a macrolide antibiotic structurally closely related to Erythromycin. Oleandomycin is similar to Erythromycin with antimicrobial activity.

In the second place, Oleanolomycin is an important 14 membered macrolide antibiotic in clinic. Obviously, Oleanolomycin is a macrolide antibiotic produced by Streptomyces. It contains two sugars attached to glycoside ligands: l-oleander sugar and d-disaccharide amine. Additionally, Oley encodes a methyltransferase involved in the biosynthesis of l-oleander sugar.

Last but not the least, the cell extract of Streptomyces, an antibiotic that produces Oleanolomycin, can inactivate Oleanolomycin in the presence of UDP glucose.

All in all, Oleandomycin is a macrolide antibiotic.


Vilches C, et al. J Bacteriol. 1992 Jan;174(1):161-5.