GLP-26 is a HBV Capsid Assembly Modulator
Hepatitis B virus (HBV) is a small DNA virus with unusual features similar to retroviruses. HBV is a prototype virus of the Hepadnaviridae family. HBV infections represent a significant burden…
Hepatitis B virus (HBV) is a small DNA virus with unusual features similar to retroviruses. HBV is a prototype virus of the Hepadnaviridae family. HBV infections represent a significant burden…
Histone deacetylase (HDAC) enzymes, including subtypes comprising class I (HDAC1, HDAC2, HDAC3, and HDAC8) and class II (HDAC 4–7, HDAC9 and HDAC10), control the deacetylation of histone and non-histone proteins.…
Recent research shows that RIP1 kinase activity is an important driver of TNF-mediated inflammation and pathology. Genetic evidence of mice supports it. The mutations shunt signaling down the RIP1 kinase…
As previously introduced, we all have known that RRx-001, a hypoxia-selective epigenetic agent and a radio- and chem-sensitizer. Additionally, it triggers apoptosis and overcomes drug resistance in myeloma. RRx-001 exhibits…
Infiltration of leukocytes from the peripheral circulation into tissues such as the gut mucosa is an important aspect of immune surveillance. They interact with cytokine or other proinflammatory stimuli-activated endothelial…
Abdominal aortic aneurysm (AAA) is a localized enlargement of the abdominal aorta, larger than normal. It commonly causes no symptoms, but sometimes it has symptoms through pushing on the abdomen.…
The blockade of the PD-1/PD-L1 immune checkpoint pathway with monoclonal antibodies has provided significant advances in cancer therapy. However, the antibody-based immunotherapies carry a number of disadvantages, including the high…
CXCL17 is a mucosal chemokine that associates with human diseases including idiopathic pulmonary fibrosis (IPF) and cancer. CXCL17 is an antimicrobial mucosal chemokine that may play a role in the…
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase. Syk plays an important role in allergic diseases and inflammation. Thus, Syk is an attractive target for therapeutic kinase inhibitors. This…