Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family. Besides, it regulates signal transduction downstream of the IL-23/IL-12 pathway and the type I interferon family receptor, pairing…
The Janus kinase (JAK) family of protein-tyrosine kinase has four members: JAK1, JAK2, JAK3, and TYK2. The Janus kinases share seven distinct JAK homology (JH1-JH7) domains. These proteins possess an…
Janus kinases (JAKs) are cytoplasmic tyrosine kinases. JAKs link cytokine signaling from membrane receptors to signal transducer and activator of transcription (STAT). Furthermore, the JAK-STAT signal pathway transfers the extra-membrane…
Interleukin-2 (IL-2) is a pleiotropic cytokine and controls the differentiation and homeostasis of both pro- and anti-inflammatory T cells. The IL-2 receptor couples to JAK tyrosine kinases and activates the…
Psoriasis and inflammatory bowel diseases (IBD), both of them are chronic inflammatory diseases. The characterizes of Psoriasis are mainly red and scaly skin plaques. The topical application of corticosteroid is…
JAK/STAT-dependent cytokines are essential for the development, proliferation, and function of T-cells. The JAK family of nonreceptor tyrosine kinases is composed of four isoforms: JAK1, JAK2, JAK3, and TYK2. Functioning…
Autoimmune diseases are condition arising from an abnormal immune response to a normal body part. Autoimmune diseases are generally characterized by a dysregulation of cytokine signaling. Cytokine signaling is an…