A robust antibody response is essential for efficient identification and eradication of pathogenic microbes and toxins. Dysregulation of the antibody response can lead to autoimmune disease. Specific antigen encounter by…
Bruton’s tyrosine kinase (BTK), a member of the Tec family of tyrosine kinases, is expressed in B cells, macrophages, and monocytes, but not in T cells. Mutations in the human…
Chronic obstructive pulmonary disease (COPD) is a kind of lung disease. The symptoms are obvious, including shortness of breath and cough with sputum production. It always worsens over time. p38…
Human immunodeficiency virus (HIV) infection causes CD4 T cell depletion and immunodeficiency. Antiretroviral drugs target viral proteins, such as reverse transcriptase, protease, and integrase. Antiretroviral drugs effectively inhibit HIV. However,…
In the previous article “KRN5 is a Nuclear Factor of Activated T Cells 5 (NFAT5) Suppressor”, we introduced a novel NFAT5 suppressor KRN5. And the suppressor is the derivative of…