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Tag: PAH

PF-543 is a Selective and Reversible SPHK1 Inhibitor

2020-10-06 Edward Jenner

S1P (sphingosine 1-phosphate) is an extracellular ligand at five cognate GPCRs and a consequential intracellular lipid intermediate. It affects diverse…

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Posted in: Cardiovascular Filed under: Apoptosis, Autophagy, Necrosis, PAH, SPHK1

L-902688 is a Selective and Orally Active EP4 Receptor Agonist

2020-03-11 Edward Jenner

Right ventricular (RV) hypertrophy and failure are the main causes of morbidity and mortality with pulmonary arterial hypertension (PAH) in…

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Posted in: Fibrosis Filed under: EndMT, EP4, PAH

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