![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/12/CB-5083-is-a-Selective-and-Orally-Bioavailable-p97-Inhibitor-2020-12-17.jpg)
The AAA+ ATPase p97 is essential to a wide range of cellular functions. The p97 acts downstream from ubiquitin signaling…
Degradation of proteins in mammalian cells via two distinct pathways: lysosome-dependent and proteasome-dependent. PR-39 is a proline- and arginine-rich antibacterial peptide.…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/08/LXE408-is-an-Orally-Active-Proteasome-Inhibitor-with-Anti-leishmaniasis-Activity-2020-08-22.jpg)
Proteasomes are protein complexes that degrade unwanted or damaged proteins by proteolysis, which can destroy peptide bonds. Specifically, proteasomes are…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/09/ML604440-is-a-Specific-Proteasome-β1i-LMP2-Subunit-Inhibitor-2019-09-15.jpg)
The ubiquitin-proteasome system exerts numerous essential regulatory functions in almost all cell biological pathways. The 26S proteasome degrades polyubiquitylated protein…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/05/KZR-504-Highly-Selective-Inhibitor-of-Immunoproteasome-Low-Molecular-Mass-Polypeptide-2-2019-05-21.jpg)
A study from Henry W. B. Johnson discovered and described KZR-504 as a highly selective inhibitor of immunoproteasome low molecular…