Degradation of proteins in mammalian cells via two distinct pathways: lysosome-dependent and proteasome-dependent. PR-39 is a proline- and arginine-rich antibacterial peptide. It is also a noncompetitive, reversible, and allosteric proteasome inhibitor. PR-39 reversibly binds…
Proteasomes are protein complexes that degrade unwanted or damaged proteins by proteolysis, which can destroy peptide bonds. Specifically, proteasomes are part of the main mechanism by which cells regulate the…
The ubiquitin-proteasome system exerts numerous essential regulatory functions in almost all cell biological pathways. The 26S proteasome degrades polyubiquitylated protein substrates and consists of a 19S regulator bearing ubiquitin receptors…
A study from Henry W. B. Johnson discovered and described KZR-504 as a highly selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2). Immunoproteasome is always expressed in nonhematopoietic…