The AAA+ ATPase p97 is essential to a wide range of cellular functions. The p97 acts downstream from ubiquitin signaling…
Degradation of proteins in mammalian cells via two distinct pathways: lysosome-dependent and proteasome-dependent. PR-39 is a proline- and arginine-rich antibacterial peptide.…
Proteasomes are protein complexes that degrade unwanted or damaged proteins by proteolysis, which can destroy peptide bonds. Specifically, proteasomes are…
The ubiquitin-proteasome system exerts numerous essential regulatory functions in almost all cell biological pathways. The 26S proteasome degrades polyubiquitylated protein…
A study from Henry W. B. Johnson discovered and described KZR-504 as a highly selective inhibitor of immunoproteasome low molecular…