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Tag: TNF

UCB-9260 Inhibits TNF Signalling by Stabilising an Asymmetric form of the Trimer

2021-02-10 Edward Jenner

Tumor necrosis factor (TNF) is a cytokine belonging to a family of trimeric proteins. This factor acts as a key…

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Posted in: Arthritis, Collagen-Induced Arthritis Filed under: CAIA, TNF

GS-6201 is a Selective Adenosine A2B Receptor Antagonist

2020-01-26 Edward Jenner

Adenosine is an endogenous purine nucleoside present in every cell of the human body. Four distinct adenosine receptor subtypes are…

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Posted in: Allergy, Inflammation Filed under: Adenosine, IL-6, TNF

CU-T12-9 is a Specific TLR1/2 Agonist

2020-01-01 Edward Jenner

Toll-like receptors belong to a family of pattern recognition receptors, regulate innate immunity and subsequent adaptive immune responses. TLRs can…

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Posted in: Inflammation Filed under: iNOS, Interleukin, TLR, TNF

CU-CPT22 is a TLR1-TLR2 Complex Inhibitor

2019-10-27 Edward Jenner

Toll-like receptors (TLRs) are type I transmembrane proteins. They can recognize pathogen-derived macromolecules, thereby playing a key role in the…

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Posted in: Inflammation Filed under: Interleukin, Pam3CSK4, TLR, TNF

Motolimod is a Selective TLR8 Agonist

2019-10-25 Edward Jenner

Motolimod (VTX-2337) is a selective Toll-like receptor (TLR) 8 agonist. In vitro, HEK293 cells with various human TLRs, only Motolimod activates…

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Posted in: Immunotherapy Filed under: IFN, Interleukin, TLR, TNF

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