CH-0793076, a Hexacyclic Camptothecin Analog, Inhibits DNA Topoisomerase I
CPT-11 and Topotecan are two potent DNA topoisomerase I inhibitors in clinical. CPT-11 is the prodrug of SN-38. Topotecan is a water-soluble semisynthetic derivative of Camptothecin. CPT-11 is mainly for…