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AG-1478 is a Selective EGFR Tyrosine Kinase Inhibitor
Epidermal growth factor receptor (EGFR) is a transmembrane protein and a member of the ErbB receptor family. Specifically, EGFR is a tyrosine kinase in various tissues and mediates cell proliferation,…
Poziotinib is an Orally Active and Irreversible pan-HER Inhibitor
The HER protein is a transmembrane tyrosine kinase receptor and a member of the epidermal growth factor receptors (EGFRs) family. HER2 acts as an oncogene in carcinomas. In particular, HER2…
PD-166793 is a Selective and Orally Active MMP Inhibitor
Matrix metalloproteinases (MMPs) are a protein family of zinc-containing endopeptidases. Especially, MMPs are essential in (neuro)inflammation. MMPs act as enzymes capable of catalyzing the hydrolysis of collagen. MMP-3 binds to…
Osimertinib is an Irreversible and Mutant Selective EGFR Inhibitor
Epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase protein. EGFR plays an important role in controlling cell division and survival. Osimertinib (AZD9291) is a mutant-selective, irreversible inhibitor…
TML-6 Inhibits the Synthesis of the β-amyloid Precursor Protein and β-amyloid
Amyloid beta (Aβ) is a major component of amyloid plaques found in the brains of patients with Alzheimer's disease. Specifically, the peptide is derived from the amyloid precursor protein (APP),…
COG1410 Exerts Neuroprotective and Antiinflammatory Effects
Apolipoprotein E (ApoE) is a protein involved in human fat metabolism. Specifically, ApoE belongs to a family of fat binding proteins called apolipoproteins. In the circulation, it exists as part…