{{unknown}}
Tapinarof is a Natural Aryl Hydrocarbon Receptor (AhR) Agonist
Tapinarof (GSK2894512) is a naturally-derived small molecule produced by bacterial symbionts of entomopathogenic nematodes. Especially, Tapinarof displays significant efficacy in psoriasis and atopic dermatitis (AD) modls. Psoriasis vulgaris is a…
Rolipram is a Selective Phosphodiesterases PDE4 Inhibitor
Phosphodiesterases (PDEs) are enzymes that convert cyclic nucleotides (cAMP and cGMP) to their corresponding 5′-AMP and 5′-GMP in order to inactivate the cyclic nucleotides. There are currently 11 members in…
Purmorphamine is a Smoothened/Smo Receptor Agonist
Smoothened (Smo), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog (Hh) signal across the cell membrane. The canonical Hh pathway functions through major Hh molecules such…