Zatebradine is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
Zatebradine (UL-FS-49) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 of 1.96 µM. Zatebradine reduces the dose-dependently the amplitude of the cardiac pacemaker current (If),…