3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer. Firstly, in B16-F10 melanoma cells, 3M-011 treatment can decrease B16-F10 melanoma cell counts as a dose-dependent manner. 3M-011 potentiates…
Toll-like receptors belong to a family of pattern recognition receptors, regulate innate immunity and subsequent adaptive immune responses. TLRs can up-regulate costimulatory molecules on antigen-presenting cells (APCs) to activate adaptive…
Chronic hepatitis C (CHC) virus infection continues to be a significant health burden, and 2–3% of the global population infected by the hepatitis C virus (HCV). The innate immune response…
Toll-like receptor (TLR) family proteins belong to PRRs. They play a crucial role in the initiation of the hosts’ immune responses, linking innate immunity and adaptive immunity. TLRs recruit a…
The innate immune system senses the presence of pathogen associated molecular patterns (PAMPs) through a wide variety of germ-line encoded host sensors. They are pattern recognition receptors (PRRs). Toll-like receptor…