Menin is a protein encoded by the MEN1 gene. MLL fusion proteins interact directly with menin to regulate the expression of MEIS1 and HOX genes, which drive leukemogenesis in MLL…
MYC proteins include MYC (also known as c-MYC), MYCL, and MYCN. They play critical roles in tumorigenesis and therapeutic resistance. MYC proteins are implicated in up to 70% of all human…
Recruitment of myeloid-derived suppressor cells (MDSCs) into tumors induces local immunosuppression in carcinomas. CXCR2+ neutrophilic MDSCs (PMN-MDSCs) are the most abundant myeloid cell subset within oral and lung syngeneic carcinomas….
The innate immune system senses the presence of pathogen associated molecular patterns (PAMPs) through a wide variety of germ-line encoded host sensors. They are pattern recognition receptors (PRRs). Toll-like receptor…
Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRR). They play an essential role in coordinating innate and adaptive immunity to protect the host from bacteria, viruses, other…