Phosphatidylinositol-4-phosphate 5-kinase type-1C (PIP5K1C) is a lipid kinase that regulates focal adhesion dynamics and cell attachment through the site-specific formation of phosphatidylinositol ,5-bisphosphate (PI4,5P2). Numerous pain-producing (pronociceptive) receptors signal via…
Mammalian cell division involves an orderly progression through four distinct phases: G1 (growth phase 1), S (DNA synthesis), G2 (growth phase 2), and M (mitosis). During the G1 phase, cells…
Exosomes act as vesicles of endosomal origin secreted from reticulocytes. Exosomes bear proteins, lipids, and RNAs, mediating intercellular communication between different cell types in the body, and thus affecting normal…
COX-2 is the more important source of prostanoid formation in inflammation and in proliferative diseases. In particular, COX-2 prefers prostaglandin I synthase and the microsomal PGES isozymes. DuP-697 is an…
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant myeloid cell infiltrates. The immunosuppression, fibrosis, T cell dysfunction, and poor prognosis in patients with PDAC associate with these infiltrates. The cells…