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Tag: Anti-Tumor

KMH-233 is a Reversible and Selective LAT1 Inhibitor

2021-01-18 Edward Jenner

Amino acids are essential for protein synthesis, they are supporting cell growth, and metabolism. System L belongs to the family…

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Posted in: Cancer Immunology Filed under: Anti-proliferative, Anti-Tumor, Breast Cancer, LAT1

CB-5083 is a Selective and Orally Bioavailable p97 Inhibitor

2020-12-17 Edward Jenner

The AAA+ ATPase p97 is essential to a wide range of cellular functions. The p97 acts downstream from ubiquitin signaling…

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Posted in: Cancer Immunology Filed under: Anti-Tumor, Apoptosis, ATPase, Multiple Myeloma, p97, Proteasome, TPD

iGOT1-01 is a Potent Aspartate Aminotransferase 1 (GOT1) Inhibitor

2020-11-26 Edward Jenner

Glutamate-oxaloacetate transaminase (GOT) is a Pyr aldehyde phosphate-dependent enzyme. Specifically, it exists in the form of cytoplasm and mitochondria, GOT1,…

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Posted in: Cancer Immunology Filed under: Anti-Tumor, DLD1, Drugdiscovery, GOT1

CH-0793076, a Hexacyclic Camptothecin Analog, Inhibits DNA Topoisomerase I

2020-09-26 Edward Jenner

CPT-11 and Topotecan are two potent DNA topoisomerase I inhibitors in clinical. CPT-11 is the prodrug of SN-38. Topotecan is…

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Posted in: Cancer Immunology Filed under: Anti-Tumor, BCRP, Camptothecin, Topoisomerase I

SC-58125 is a Potent and Selective COX-2 Inhibitor

2020-09-05 Edward Jenner

Nonsteroidal anti-inflammatory agents (NSAIDs) are useful for the treatment of inflammatory diseases. In particular, NSAIDs inhibit the enzyme cyclooxygenase (COX),…

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Posted in: Inflammation Filed under: Anti-Tumor, COX-2, G2 Arrest, PGE2

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Anti-Inflammatory Anti-Tumor Antibacterial Antimalarial Antitumor Antiviral Apoptosis Autophagy Breast Cancer Btk Chemokines COPD COX Cytokine EGFR ER Stress HBV HCV HDAC HIV IFN IL-6 IL-17 Infection Integrin Interferon Interleukin Leukemia Low Toxicity Multidrug Resistance Necroptosis NF-κB p38 MAPK PI3K PPI Proteasome RIPK STAT STING T Cell Th17 TLR TNF TNF-α α4β1
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