Amino acids are essential for protein synthesis, they are supporting cell growth, and metabolism. System L belongs to the family…
The AAA+ ATPase p97 is essential to a wide range of cellular functions. The p97 acts downstream from ubiquitin signaling…
Glutamate-oxaloacetate transaminase (GOT) is a Pyr aldehyde phosphate-dependent enzyme. Specifically, it exists in the form of cytoplasm and mitochondria, GOT1,…
CPT-11 and Topotecan are two potent DNA topoisomerase I inhibitors in clinical. CPT-11 is the prodrug of SN-38. Topotecan is…
Nonsteroidal anti-inflammatory agents (NSAIDs) are useful for the treatment of inflammatory diseases. In particular, NSAIDs inhibit the enzyme cyclooxygenase (COX),…