Kinases typically integrate signaling events down-stream of multiple cytokine receptors. Hence, kinase inhibitors distinguish themselves from cytokine-targeted biologicals by their capacity to modulate multiple signaling pathways simultaneously. IL-1 receptor (IL-1R)–associated…
IRAK-4 (interleukin-1 receptor-associated kinase 4) is a protein kinase involved in signal transduction of innate immune response from toll-like receptors. Specifically, it also supports signal transduction from T cell receptors.…
IRAK4 (interleukin-1 receptor-associated kinase 4) is a protein kinase in the IRAK family. Specifically, IRAK-4 is relevant to signal transduction of innate immune response from toll-like receptors. It also supports…
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key node in innate inflammatory signaling. It is also directly downstream of the Toll-like receptors (TLRs) and interleukin-1 (IL-1) family of receptors. Besides,…