Darapladib is a Potent Lp-PLA2 Inhibitor for Atherosclerosis and Cancer Research
Darapladib is an orally active, selective and reversible Lp-PLA2 inhibitor, with an IC50 value of 0.25 nM.
Darapladib is an orally active, selective and reversible Lp-PLA2 inhibitor, with an IC50 value of 0.25 nM.
Sphingosine-1-phosphate (S1P) is a signaling sphingolipid, also known as lysosphingolipid. It is a bioactive lipid mediator, found in body fluids and tissues. S1P regulates lymphocyte recirculation, cardiac function and a…
GABA (γ-aminobutyric acid-gated) is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. Besides, Its principal role is reducing neuronal excitability throughout the nervous system. GABACl (γ-aminobutyric…
Chronic hypoxia leads to pulmonary hypertension and pulmonary vascular remodelling in many mammalian species. Hypoxic pulmonary vasoconstriction (HPV) is thought to play a key role in the development of pulmonary…
Sphingosine 1-phosphate (S1P) is a bioactive lipid molecule secreted into the circulation mainly by erythrocytes and endothelial cells. First of all, S1P acts via G protein-coupled S1P receptors (S1PRs), is…
Kv1.3 is a classic shaker-type potassium channel with six transmembrane segments that was discovered in the early 1980s in a non-excitable cell, T lymphocytes. Kv1.3 is the first K+; channel…
Gamma-aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the vertebrate central nervous system. It is also a precursor of gamma‐hydroxybutyric acid (GHB). The GABA receptors are a class of…
JAK is a family of cytoplasmic tyrosine kinases consisting of four isoforms, JAK1, JAK2, JAK3 and TYK2. According to studies, JAKs transduce cytokine-mediated signals through the family of signal transducers…