AZD8797 is an Orally Active Antagonist of CX3CR1 Receptor
Multiple sclerosis is a demyelinating disease with damaged insulating covers of nerve cells in the brain and spinal cord. It is a kind of inflammatory disease, affects the central nervous…
Multiple sclerosis is a demyelinating disease with damaged insulating covers of nerve cells in the brain and spinal cord. It is a kind of inflammatory disease, affects the central nervous…
NF-κB is a transcription factor with heterodimer or homodimer form of rel family proteins such as RelA (p65), RelB, cRel, p50 and p52. NF-κB binds to inhibitory κB (IκB) proteins…
Various types of cytokinesuchemokines react with their receptors. They transduce extracellular signals into intracellular response through a mitogen-activated protein kinase (MAPK) signalling cascade. Furthermore, p38 MAPK signalling might play an…
Currently, a void exists for serine/threonine protein kinase inhibitor drugs and central nervous system indications. Stress kinases are of special interest in neurological and neuropsychiatric disorders, because of their involvement…
The 5-lipoxygenase (LOX) pathway plays an important role in the pathophysiology of asthma. 5-LOX is an important arachidonic acid-metabolizing enzyme producing leukotrienes and other proinflammatory lipid mediators. Moreover, it has…
In previous blogs, we have introduced a few MAPK p38 inhibitors. As a result, MAPK p38 plays an important role in many diseases, including cancer and inflammatory diseases. Today, I’d…
The immune system is a powerful host defense mechanism specializing in antigen recognition. Besides, loss of tolerance to self-antigens results in pathological conditions which are manifested as autoimmune diseases. Moreover,…
Prostaglandin EP2 receptor (PGE2) is a potential neuroprotection target in epilepsy and other inflammation-related neurological disorders. Activation of PGE2 subtype EP2 promotes inflammation. The EP2 receptor widely expresses in both…
Interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK or TXK) are essential mediators of intracellular signaling in both normal and neoplastic T-cells and natural killer (NK) cells. Thus, ITK…
Systemic sclerosis is an autoimmune disease of the connective tissue. The symptom is thickening of the skin due to collagen accumulation or injuries to small arteries. As we all know,…